Everything about Stratum Spinosum totally explained
In the
skin, the
stratum spinosum is a multi-layered arrangement of cuboidal cells that sits beneath the
stratum granulosum. Adjacent cells are joined by
desmosomes, giving them a spiny appearance when the cells shrink during the staining process while the desmosomes hold firm. Their
nuclei are often darkened (a condition called
pyknosis), which is an early sign of cell death. Their fate is sealed because the nutrients and oxygen in interstitial fluid have become exhausted before the fluid is able to reach them by diffusion.
Cells of the stratum spinosum actively synthesize
intermediate filaments called cytokeratins, which are composed of
keratin. These intermediate filaments are anchored to the desmosomes, joining adjacent cells to provide structural support, helping the skin resist abrasion.
Additional images
Image:Skin.jpg|Cross-section of all skin layers.
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